Institute for Systems Biology
Nonprofit profile at a glance
- EIN
- 912003593
- IRS 990 coverage
- 2008–2024
- Official website data refreshed
- Sep 2026
- Forms available
- Form 990 2024, Form 990-T 2024
- Location
- Seattle, WA, USA
- Phone
- 206-732-1200
- Rating
- 79
- Verdict
- SUPPORTED
- Rating confidence
- Standard
- Sector
- Biological & Life Sciences
Reported finances
- Revenue
- $42,255,091
- Expenses
- $47,550,054
- Assets
- $109,279,173
- Liabilities
- $50,419,677
Source: IRS Form 990. Selected filing: tax year 2024. Amounts in USD.
Leadership & pay
26 people listed
Executive titles in this filing
- JAMES R HEATH PHD (PRESIDENT/PROFESSOR)
Highest reported compensation
- WASIF RASHEED (DIRECTOR - THRU 3/24): $3,178,068 total reported compensation
- HODA ASMAR MD (DIRECTOR (PART YEAR)): $2,697,869 total reported compensation
- ARI ROBICSEK MD (DIRECTOR): $2,234,491 total reported compensation
Source: IRS Form 990. Selected filing: tax year 2024. Names and roles reflect this filing, not necessarily current officeholders.
Overview
Mission
The Institute for Systems Biology (ISB) is a nonprofit scientific research organization located in Seattle. We believe that science has the power to transform health.
What it reported doing in 2024
See schedule oat providence, we use our voice to advocate for vulnerable populations and needed reforms in health care. We are also pursuing innovative ways to transform health care by keeping people healthy, and making our services more convenient, accessible and affordable for all. In an increasingly uncertain world, we are committed to high-quality, compassionate health care for everyone - regardless of coverage or ability to pay. We help people and communities benefit from the best health care model for the future - today.together, our 125,000 caregivers (all employees) serve in 51 hospitals, 1,014 clinics and a comprehensive range of health and social services across Alaska, California, Montana, New Mexico, Oregon, Texas and Washington. The providence affiliate family includes:-providence across five western states-covenant health in west Texas and New Mexico-facey medical group in los angeles, ca-kadlec in southeast Washington-pacific medical centers in seattle, wa-swedish health services in seattle, wain 2024, providence ministries and affiliates provided $1.9 billion in community benefit programs. This includes free and discounted care, uncompensated and subsidized care, and other community health activities.one of these vital programs, medicaid, is a lifeline for millions of individuals, including seniors, children, pregnant patients, those with disabilities and veterans. We are grateful to everyone in our communities who has joined us in advocating for continued funding and expansion of this program. Together, we are helping to ensure more people have access to needed care.for more information go to: https://www.providence.org/about/annual-reportthrough our community benefit programs, we focus on meeting the diverse needs of the people we serve by working to ensure basic health needs are met, removing barriers to care, building community resilience and innovating for the future. Providence continues to work towards carbon negative and in 2024 decreased emissions by 19 percent compared to our 2019 baseline. Our efforts earned us a system record 55 environmental excellence awards from practice greenhealth and made us the first large system to receive the joint commission's sustainable healthcare certification in 2024 for each of our hospitals.program service accomplishmentsbiomolecular research: in 2024, isb researchers published 131 academic research papers in a range of high-profile journals. Topics covered included covid-19, genomics, microfluidics, proteomics, high-throughput computation, multiscale modeling, systems biology applications, bioinformatics, global health, and cancers.isb education & outreachisb education's program activities reported for the 2024/25 school year are listed below in five categories.our vision is that students graduate ready to learn, thrive, work and engage in a stem-rich society. We want every student to have an opportunity to do real science we bring current science and authentic practices to schools.1- combined activities across two isb education groupspartners and funders:-12 monthly impact stories were written by the isb education team to communicate regularly with partners and funders. Https://isbscience.org/news/education/2024-25-school-year-isb-education-highlights/-10 partnerships continues, with regional school districts and other non-profit organizations-7 presentations were given at events for regional, state, and national audiences.school systems: "climetime" https://www.climetime.org/cbo-grantees/isb/-4 workshop series were provided for elementary and secondary science teachers.-93 educators, across the range of grades: elementarymiddle-and high school.-35 school districts had educators participating in the events.-8 educational service district regions across wa state had educators participating in the events.stem professionals:-50+ stem professionals contributed to the above education activities, to support learning experiences for students, teachers, and principals.2- b
Operating model
- Revenue model
- Mixed. Its operating money came from several sources; no one source provided a clear majority.
- Distribution model
- Direct operator. The filing allocates 100% of reported program-service expenses outside its grant, affiliate-payment, and member-benefit lines. This expense classification does not rule out separately announced grant awards.
The verdict
SUPPORTED - A large share of available resources goes toward mission work and the filed numbers largely add up. Expenses are high relative to revenue and revenue has declined or grown slowly.
Rating breakdown
- Financial Efficiency: 80
- Transparency & Controls: 85
- Accountability: 85
- Sustainability: 31
- Growth: 60
Detailed rating inputs
Financial Efficiency
- Mission deployment rate: 84%; rating input score 84
- Program expense ratio: 71.1%; rating input score 71
- Fundraising efficiency: $87.73 raised per $1 spent on fundraising; rating input score 83; 83rd percentile among comparable filings
Transparency & Controls
- Consistency checks: 100%; rating input score 100; 62nd percentile among comparable filings
- Pay-setting controls: 3 of 6 controls in place; rating input score 50
- Compensation committee: Missing
- Independent consultant: Missing
- Other Form 990s reviewed: Missing
- Written employment contract: Pass
- Compensation survey or study: Pass
- Board or committee approval: Pass
- Foreign activity oversight: Limited
- Grant itemization coverage: Limited
- Major donor itemization: Yes; rating input score 100
- Related-party transparency: Yes; rating input score 100
Accountability
- Independent voting board: 75%; rating input score 75; 14th percentile among comparable filings
- Governance controls: 9 of 9 controls in place; rating input score 100
- Conflict-of-interest policy: Pass
- Whistleblower policy: Pass
- Document-retention policy: Pass
- CEO compensation review process: Pass
- Other executive compensation review process: Pass
- Form 990 shared with the board: Pass
- Board meeting minutes documented: Pass
- Audit committee oversight: Pass
- Independent financial-statement audit: Pass
Sustainability
- Operating margin: -12.5%; rating input score 8; 8th percentile among comparable filings
- Total-asset coverage ratio: 2.3; rating input score 66; 66th percentile among comparable filings
- Liabilities to assets ratio: 0.46; rating input score 32; 32nd percentile among comparable filings
- Officer compensation ratio: 6.9%; rating input score 36; 36th percentile among comparable filings
Growth
- Program expense growth: 2.3% per year; rating input score 100; 21st percentile among comparable filings
- Revenue growth: -0.7% per year; rating input score 0; 6th percentile among comparable filings
- Asset growth: 7.7% per year; rating input score 100; 53rd percentile among comparable filings
Details
- What they do: 6 programs and campaigns described on the official site · 1 operating location identified
- Where the money goes: 84% of revenue deployed · 71.1% of spending went to programs
- Governance: 12 of 16 board members independent · 9 of 9 filing controls reported
- Programs: 1 filed program accomplishment · $33.8M in reported program spending
- Leadership: top reported pay $3.2M · 26 people listed · 3 of 6 pay-setting controls reported
- Highest-paid contractors: 5 contractors listed · $5.6M reported
- Consistency: 33 of 34 current checks pass · 1 finding to review
- Schedules: 6 filed schedules · includes major donors, executive pay, and related organizations
- Filing history: 15 filing years from 2008 to 2024
- Contacts: How to reach this organization
- Money network: 9 filed money-flow records
- Related organizations: 175 filed related-organization links
- Grant readiness: Federal tax and exclusion status, award history, and grant-maker relationships.
- People: Everyone the filings name, and which of them the filings identify by more than a name.
- Staff and benefit plans: Retirement and health plans the organization files with the Department of Labor, and the people in them.
Key Signals
Signals prioritize questions for review. They are not findings of misconduct.
- High — Sustainability: Operating margin scored 8/100.
- High — Growth: Revenue growth scored 0/100.
- Moderate — Transparency & Controls: Schedule A contributions reconciliation did not reconcile in the filed values.
- Moderate — Sustainability: Liabilities to assets ratio scored 32/100.
- Moderate — Sustainability: Officer compensation ratio scored 36/100.