Xenobe Research Institute
Nonprofit profile at a glance
- EIN
- 201624945
- IRS 990 coverage
- 2022–2024
- Forms available
- Form 990 2024, Form 990-EZ 2021
- Location
- San Diego, CA, USA
- Phone
- 8584013083
- Rating
- 68
- Verdict
- SUPPORTED
- Rating confidence
- Moderate
Reported finances
- Revenue
- $174,939
- Expenses
- $131,801
- Assets
- $271,239
- Liabilities
- $0
Source: IRS Form 990. Selected filing: tax year 2024. Amounts in USD.
Leadership & pay
2 people listed
Executive titles in this filing
- James J La Clair (President)
Highest reported compensation
- James J La Clair (President): $44,352 total reported compensation
Source: IRS Form 990. Selected filing: tax year 2024. Names and roles reflect this filing, not necessarily current officeholders.
Overview
Mission
The Xenobe Research Institute conducts research on natural and synthetic small molecule therapeutics with the ultimate goal of discovering and ultimately translating new materials for clinical trials. Funds were obtained from two projects one supported by the NIH and the other by Terra Bioworks
What it reported doing in 2024
National Institutes of Health Grant R21NS128597. While well established as clinical targets, the lack of molecular probes to the large immunophilins continues to inhibit our ability to evaluate and drug them clinically. This program explores the development of a general platform to discover probes that target specific domains within a neurological protein. Using cyclophilin 40 (Cyp40), FK506-binding proteins FKBP51 and FKBP52, our team seeks to define critically needed reagents to understand the role of the `large immunophilin' family in neurological disease. We began studies on our recently funded R21 program and have reported signficance success within our initial year of funding.The revenue generated will be used for the latter half of the program. A two year award was provided within this funding period. These funds to cover salaries, research supplies, instrument time, and equipment access to complete these studies.
Operating model
- Revenue model
- Grant-funded. 85% of the money available for current operations came from government grants.
- Distribution model
- Direct operator. The filing allocates 100% of reported program-service expenses outside its grant, affiliate-payment, and member-benefit lines. This expense classification does not rule out separately announced grant awards.
The verdict
SUPPORTED - A large share of available resources goes toward mission work and the filed numbers largely add up. A relatively small share of voting board members are independent and some filing-based governance responses are negative or unanswered.
Rating breakdown
- Financial Efficiency: 75
- Transparency & Controls: 86
- Accountability: 21
- Sustainability: 65
- Growth: 100
Detailed rating inputs
Financial Efficiency
- Mission deployment rate: 75.3%; rating input score 75
- Program expense ratio: 100%; rating input score 100
- Fundraising efficiency: Limited
Transparency & Controls
- Consistency checks: 91.7%; rating input score 92; 19th percentile among comparable filings
- Pay-setting controls: Limited
- Foreign activity oversight: Limited
- Grant itemization coverage: Limited
- Major donor itemization: Yes; rating input score 100
- Related-party transparency: Limited
Accountability
- Independent voting board: 0%; rating input score 0; 7th percentile among comparable filings
- Governance controls: 4 of 8 controls in place; rating input score 50
- Conflict-of-interest policy: Pass
- Whistleblower policy: Pass
- Document-retention policy: Fail
- CEO compensation review process: Fail
- Other executive compensation review process: NotApplicable
- Form 990 shared with the board: Pass
- Board meeting minutes documented: Pass
- Audit committee oversight: Missing
- Independent financial-statement audit: Fail
Sustainability
- Operating margin: 24.7%; rating input score 78; 78th percentile among comparable filings
- Total-asset coverage ratio: 2.06; rating input score 60; 60th percentile among comparable filings
- Liabilities to assets ratio: 0; rating input score 80; 80th percentile among comparable filings
- Officer compensation ratio: 33.7%; rating input score 9; 9th percentile among comparable filings
Growth
- Program expense growth: 4.8% per year; rating input score 100; 53rd percentile among comparable filings
- Revenue growth: 0.1% per year; rating input score 100; 24th percentile among comparable filings
- Asset growth: 16.2% per year; rating input score 100; 79th percentile among comparable filings
Details
- Where the money goes: 75.3% of revenue deployed · 100% of spending went to programs
- Governance: 0 of 2 board members independent · 4 of 8 filing controls reported
- Programs: 3 filed program accomplishments · $132K in reported program spending
- Leadership: top reported pay $44K · 2 people listed
- Consistency: 39 of 40 current checks pass · 1 finding to review
- Schedules: 3 filed schedules · includes major donors
- Filing history: 3 filing years from 2022 to 2024
- Contacts: How to reach this organization
- Money network: 2 filed money-flow records
- Grant readiness: Federal tax and exclusion status, award history, and grant-maker relationships.
- People: Everyone the filings name, and which of them the filings identify by more than a name.
Key Signals
Signals prioritize questions for review. They are not findings of misconduct.
- High — Accountability: Independent voting board scored 0/100.
- Review — Accountability: Governance controls: 3 of 7 not reported.
- Moderate — Transparency & Controls: Schedule A contributions reconciliation did not reconcile in the filed values.
- High — Sustainability: Officer compensation ratio scored 9/100.