The N 1 Collaborative Inc
Nonprofit profile at a glance
- EIN
- 882591503
- IRS 990 coverage
- 2023–2025
- Forms available
- Form 990 2025, Form 990-EZ 2022
- Location
- Somerville, MA, USA
- Phone
- 7726789669
- Rating
- 69
- Verdict
- SUPPORTED
- Rating confidence
- Moderate
- Sector
- Support N.E.C.
Reported finances
- Revenue
- $894,517
- Expenses
- $323,892
- Assets
- $696,918
- Liabilities
- $6,056
Source: IRS Form 990. Selected filing: tax year 2025. Amounts in USD.
Leadership & pay
6 people listed
Executive titles in this filing
- WINSTON YAN (PRESIDENT)
People named in this filing
- WINSTON YAN (PRESIDENT)
- JULIA VITARELLO (SECRETARY)
- TIM YU (TREASURER)
Selected names, not a complete roster or a statement of current roles. Open leadership details for the complete filed list.
Source: IRS Form 990. Selected filing: tax year 2025. Names and roles reflect this filing, not necessarily current officeholders.
Overview
Mission
To make individualized medicines routinely and rapidly accessible to rare disease patients worldwide.
What it reported doing in 2025
In 2025, the organization launched two openly accessible databases to serve patients, families, researchers, and clinicians working in the individualized medicine space. The gene registry catalogs n-of-1 projects, assessed variants, and marketed genetic therapies, providing a centralized resource to advance awareness and knowledge-sharing across the individualized medicine field. The connections platform enables peer-to- peer networking across the rare disease community, linking patients and families with one another as well as with researchers and clinicians working on relevant conditions, and has grown to more than 400 community members since its launch. Both platforms are designed to reduce the information and isolation barriers that characterize ultra-rare disease. The ultimate beneficiaries are patients with ultra-rare genetic conditions and their families, who gain access to critical scientific information and a community of individuals and experts who can support their path toward treatment.
Operating model
- Revenue model
- Donor-supported. 100% of the money available for current operations came from contributions and gifts.
- Distribution model
- Direct operator. The filing allocates 100% of reported program-service expenses outside its grant, affiliate-payment, and member-benefit lines. This expense classification does not rule out separately announced grant awards.
The verdict
SUPPORTED - The filed numbers largely add up and most voting board members are independent. A relatively small share of available resources goes toward mission work and a relatively small share of total spending goes to programs.
Rating breakdown
- Financial Efficiency: 36
- Transparency & Controls: 92
- Accountability: 88
- Sustainability: 80
- Growth: 100
Detailed rating inputs
Financial Efficiency
- Mission deployment rate: 20.2%; rating input score 20
- Program expense ratio: 55.8%; rating input score 56
- Fundraising efficiency: $18.47 raised per $1 spent on fundraising; rating input score 53; 53rd percentile among comparable filings
Transparency & Controls
- Consistency checks: 100%; rating input score 100; 63rd percentile among comparable filings
- Pay-setting controls: Limited
- Foreign activity oversight: Limited
- Grant itemization coverage: Limited
- Major donor itemization: Yes; rating input score 100
- Related-party transparency: Limited
Accountability
- Independent voting board: 100%; rating input score 100; 64th percentile among comparable filings
- Governance controls: 5 of 7 controls in place; rating input score 71
- Conflict-of-interest policy: Pass
- Whistleblower policy: Pass
- Document-retention policy: Pass
- CEO compensation review process: NotApplicable
- Other executive compensation review process: NotApplicable
- Form 990 shared with the board: Pass
- Board meeting minutes documented: Pass
- Audit committee oversight: Missing
- Independent financial-statement audit: Fail
Sustainability
- Operating margin: 63.8%; rating input score 94; 94th percentile among comparable filings
- Total-asset coverage ratio: 2.15; rating input score 66; 66th percentile among comparable filings
- Liabilities to assets ratio: 0.01; rating input score 61; 61st percentile among comparable filings
- Officer compensation ratio: 0%; rating input score 78; 78th percentile among comparable filings
Growth
- Program expense growth: 12.4% per year; rating input score 100; 65th percentile among comparable filings
- Revenue growth: 53.6% per year; rating input score 100; 96th percentile among comparable filings
- Asset growth: 83.2% per year; rating input score 100; 98th percentile among comparable filings
Details
- Where the money goes: 20.2% of revenue deployed · 55.8% of spending went to programs
- Governance: 6 of 6 board members independent · 5 of 7 filing controls reported
- Programs: 3 filed program accomplishments · $181K in reported program spending
- Leadership: top reported pay $0 · 6 people listed
- Consistency: 20 of 20 current checks pass
- Schedules: 3 filed schedules · includes major donors
- Filing history: 3 filing years from 2023 to 2025
- Contacts: How to reach this organization
- Grant readiness: Federal tax and exclusion status, award history, and grant-maker relationships.
- People: Everyone the filings name, and which of them the filings identify by more than a name.
Key Signals
Signals prioritize questions for review. They are not findings of misconduct.
- High — Financial Efficiency: Mission deployment rate scored 20/100.
- Review — Financial Efficiency: Program expense ratio scored 56/100.
- Review — Financial Efficiency: Fundraising efficiency scored 53/100.
- Review — Accountability: Governance controls: Independent financial-statement audit not reported.