The Cardiometabolic Disease Research Foundation

What it reported doing in 2021

Publications from Projects funded by the Cardiometabolic Disease Research Foundation: 2008-2016 1. Fain JN, Sacks HS, Buehrer B, Bahouth SW, Garrett E, Wolf RY, Carter RA, Tichansky DS.Identification of Omentin mRNA in human epicardial adipose tissue; comparison to omentin in subcutaneous, internal mammary artery periadventitial and visceral abdominal depots. Int J Obesity 32:810-815, 2008.2. Sacks HS, Johnson E. Adipokine concentrations are similar in femoral artery and coronary venous sinus blood: evidence against in vivo endocrine secretion by human epicardial fat. Adipobiology 1:51-56, 2009 3. Sacks HS, Fain JN, Holman B, Cheema P, Chary C, Parks F, Karas J , Optican R, Bahouth SW, Garrett E, Wolf RY, Carter RA, Robbins T, Wolford D, Samaha J. Uncoupling protein-1 and related mRNAs in human epicardial and other adipose tissues: epicardial fat functioning as brown fat. J Clin Endoclinol Metab 94:3611-3615, 2009.4. Fain J, Sacks H, Bahouth S, Tichansky D, Madan A, Cheema P. Human epicardial adipokine mRNAs: comparisons with their expression in sub-sternal, subcutaneous and omental fat. Metabolism Clinical and Experimental 59:1379-1386, 2010.5. Company J, Booth F, Laughlin MH, Arce-Esquivel A, Sacks H, Bahouth SW, Fain J. Epicardial fat gene expression after aerobic exercise training in pigs with coronary atherosclerosis: relationship to visceral and subcutaneous fat. J Appl Physiol 109:1904-1912, 2010.6. Sacks HS, Fain J N, Cheema P, Karas J, Bahouth S, Garrett E, Wolf RY, Wolford D, Samaha J. Inflammatory genes in epicardial fat contiguous with coronary atherosclerosis in the metabolic syndrome and type 2 diabetes: changes associated with pioglitazone. Diabetes Care 34:730-733, 2011. 7. Sacks HS, Fain J N, Cheema P, Bahouth S, Garrett E, Wolf RY, Wolford D, Samaha J. Depot-specific over-expression of pro-inflammatory, redox, endothelial cell and angiogenic genes in epicardial fat adjacent to severe stable coronary atherosclerosis. Metab Syndr Relat Disord 9: 433-439, 2011. 8. Fain JN, Company JM, Booth FM, Laughlin MH, Padilla J, Jenkins NT, Bahouth SW, Sacks HS. Exercise training does not increase muscle FNDC5 protein or mRNA expression in pigs. Metabolism Clinical Experimental, 62: 1503-1511, 2013. 9. Sacks HS, Fain JN, Bahouth SW, Ojha S, Frontini A, Budge H, Cinti S, Symonds ME. Human Epicardial Fat exhibits Beige Features. J Clin Endoclinol Metab 98: E1488-1455, 201310. Davies GR, Birtwistle M, Pope M, Perry V, Sacks H, Budge H, Symonds M The developmental transition of epicardial, paracardial and omental adipose tissue during early life in the sheep 201311. Schultz KA, McKenney ML, Boyd JH, Byrd JP, Alloosh M, Teague SD, Arce-Esquivel AA, Fain JN, Laughlin MH, Sacks HS, Sturek M. Epicardial adipose excision slows the progression of porcine coronary atherosclerosis. J Cardiothoracic Surg 9:2-11, 201412. Ojha S, Fainberg HP, Wilson V, Pelella G, Castellanos M, May ST, Lotto AA, Sacks H, Symonds ME, Budge H. Novel gene pathway identification during the development of human epicardial fat through early life. J Clin Invest Insight 1: 2016 [Human]13. Vergnes L, Davies GR, Lin JY, Yeh MW, Livhits MJ, Harari A, Symonds ME, Sacks HS, Reue K. Augmented adipocyte browning and mitochondrial function in peri-adrenal but not subcutaneous fat in pheochromocytoma J Clin Endocrinol Metab 2016 [Human]14. McKenney-Drake ML, Rodenbeck SD, Bruning RS, Kyle W. Yancey KW, Alloosh M, Sacks HS, Sturek M. Epicardial adipose tissue removal potentiates outward remodeling and arrests coronary atherogenesis. Ann Thor Surg 2016. [Pigs]15. Aldiss P, Davies G, Woods R, Budge H, Sacks HS, Symonds ME. Browning the cardiac and peri-vascular adipose tissues to modulate cardiovascular risk. Int J Cardiol 2016.[Review]16. Winn NC, Vieira-Potter VJ, Michelle L. Gastecki ML, Welly RJ, Scroggins RJ, Zidon TM, Gaines TL, ML, Karasseva NG, Kanaley JA, Sacks HS, Padilla J. Loss of UCP1 exacerbates Western diet-induced glycemic dysregulation independent of change

Financial Efficiency

• Mission deployment rate: Limited
• Program expense ratio: 1.6%; rating input score 2

Transparency & Controls

• Consistency checks: 100%; rating input score 100; 51st percentile among comparable filings
• Major donor itemization: Limited

Sustainability

• Operating margin: Limited
• Total-asset coverage ratio: 0; rating input score 2; 2nd percentile among comparable filings
• Liabilities to assets ratio: Limited
• Officer compensation ratio: 0%; rating input score 56; 56th percentile among comparable filings

Growth

• Program expense growth: -3.4% per year; rating input score 0; 49th percentile among comparable filings
• Revenue growth: -6.2% per year; rating input score 0; 38th percentile among comparable filings
• Asset growth: -13.3% per year; rating input score 0; 12th percentile among comparable filings