Sophie's Neighborhood

Nonprofit profile at a glance

EIN
845178467
IRS 990 coverage
2020–2024
Forms available
Form 990 2024, Form 990-N 2019
Location
Boulder, CO, USA
Phone
6462757881
Rating
61
Verdict
SUPPORTED
Rating confidence
Moderate
Sector
Fund Raising and/or Fund Distribution

Reported finances

Revenue
$133,087
Expenses
$109,440
Assets
$1,020,557
Liabilities
$0

Source: IRS Form 990. Selected filing: tax year 2024. Amounts in USD.

Leadership & pay

4 people listed

Executive titles in this filing

  • LAUREN ROSENBERG (PRESIDENT-CE)

People named in this filing

  • BLAKE SEDBERRY (BOARD MEMBER)
  • MICHAEL WEINSTEIN (BOARD MEMBER)
  • HOSEA ROSENBERG (VICE PRESIDE)

Selected names, not a complete roster or a statement of current roles. Open leadership details for the complete filed list.

Source: IRS Form 990. Selected filing: tax year 2024. Names and roles reflect this filing, not necessarily current officeholders.

Overview

Mission

Sophie's neighborhood is a nonprofit dedicated to fundraising for research into the development of an effective treatment or cure for an ultra rare genetic disorder: multicentric carpotarsal osteolysis (mcto)

What it reported doing in 2024

During the fiscal year ending april 2025, sophie's neighborhood funded major research initiatives to advance understanding and treatment of multicentric carpo-tarsal osteolysis (mcto) an ultra rare genetic bone and kidney disorder. 1.advancing mcto disease mechanisms through innovative mouse models sophie's neighborhood supported research at harvard school of dental medicine investigating bone remodeling activity and cellular changes mafb mouse models of mcto. This work includes transcriptomic analyses of cells and tissues within the skeletal microenvironment to uncover molecular mechanisms driving disease progression. 2.expanding stem cell-based and developmental models of mcto in collaboration with boston children's hospital, sophie's neighborhood continued to fund studies on mafb and developmental chondrogenesis. These efforts advance stem cell-based models of mcto and identify key transcriptional networks involved in bone and cartilage development. 3.establishing critical research infrastructure for rare disease discovery sophie's neighborhood supported the creation and ongoing maintenance of mcto mouse lines with specific mafb mutations at the jackson laboratory. These specialized models enable researchers to test hypotheses related to mafb protein accumulation and disease pathology, strengthening the foundation for future therapeutic research. 4.initiate antisense oligonucleotide (aso) development and screening to evaluate therapeutic efficacy in cellular and mouse models, with the goal of reversing bone and kidney phenotypes associated with mcto.

Operating model

Revenue model
Donor-supported. 88% of the money available for current operations came from contributions and gifts.
Distribution model
Grant intermediary. The nonprofit sent 94% of its reported program spending out as grants.

The verdict

SUPPORTED - A large share of total spending goes to programs and the filed numbers largely add up. A relatively small share of voting board members are independent and a relatively small share of available resources goes toward mission work.

Rating breakdown

  • Financial Efficiency: 68
  • Transparency & Controls: 87
  • Accountability: 6
  • Sustainability: 77
  • Growth: 60

Detailed rating inputs

Financial Efficiency

  • Mission deployment rate: 48.9%; rating input score 49
  • Program expense ratio: 92.4%; rating input score 92
  • Fundraising efficiency: $190.26 raised per $1 spent on fundraising; rating input score 91; 91st percentile among comparable filings

Transparency & Controls

  • Consistency checks: 90%; rating input score 90; 9th percentile among comparable filings
  • Pay-setting controls: Limited
  • Foreign activity oversight: Limited
  • Grant itemization coverage: 97%; rating input score 97; 57th percentile among comparable filings
  • Major donor itemization: Yes; rating input score 100
  • Related-party transparency: Limited

Accountability

  • Independent voting board: 0%; rating input score 0; 7th percentile among comparable filings
  • Governance controls: 1 of 7 controls in place; rating input score 14
    • Conflict-of-interest policy: Fail
    • Whistleblower policy: Fail
    • Document-retention policy: Fail
    • CEO compensation review process: NotApplicable
    • Other executive compensation review process: NotApplicable
    • Form 990 shared with the board: Fail
    • Board meeting minutes documented: Pass
    • Audit committee oversight: Missing
    • Independent financial-statement audit: Fail

Sustainability

  • Operating margin: 17.8%; rating input score 71; 71st percentile among comparable filings
  • Total-asset coverage ratio: 9.33; rating input score 88; 88th percentile among comparable filings
  • Liabilities to assets ratio: 0; rating input score 80; 80th percentile among comparable filings
  • Officer compensation ratio: 0%; rating input score 69; 69th percentile among comparable filings

Growth

  • Program expense growth: 31.1% per year; rating input score 100; 91st percentile among comparable filings
  • Revenue growth: -35.8% per year; rating input score 0; 1st percentile among comparable filings
  • Asset growth: 9.6% per year; rating input score 100; 65th percentile among comparable filings

Details

  • Where the money goes: 48.9% of revenue deployed · 92.4% of spending went to programs
  • Governance: 0 of 2 board members independent · 1 of 7 filing controls reported
  • Programs: 1 filed program accomplishment · $101K in reported program spending
  • Leadership: top reported pay $0 · 4 people listed
  • Consistency: 18 of 19 current checks pass · 1 finding to review
  • Schedules: 4 filed schedules · includes major donors and grants
  • Filing history: 5 filing years from 2020 to 2024
  • Contacts: How to reach this organization
  • Money network: 3 filed money-flow records
  • Related organizations: 2 filed related-organization links
  • Grant readiness: Federal tax and exclusion status, award history, and grant-maker relationships.
  • People: Everyone the filings name, and which of them the filings identify by more than a name.

Key Signals

Signals prioritize questions for review. They are not findings of misconduct.

  • High — Accountability: Independent voting board scored 0/100.
  • Moderate — Financial Efficiency: Mission deployment rate scored 49/100.
  • High — Accountability: Governance controls: 5 of 6 not reported.
  • High — Growth: Revenue growth scored 0/100.
  • Review — Transparency & Controls: Domestic grant itemization did not reconcile in the filed values.