New York Structural Biology Center Inc

What it reported doing in 2024

Special projects group: the special projects group at nysbc is a team of expert scientists that performs fee-for-service protein structure determination and protein production services for external clients. In addition, they also receive funding through collaborative research projects with academic and government laboratories. They entered the second year of a five-year niaid contract using structural biology to investigate the etiologic agent for lyme disease, borreliella burgdorferi, to design a vaccine or discover antibody therapeutics against lyme disease. They also continued to participate in structural biology research projects entering the second year of a five-year niaid grant with collaborators at rutgers university investigating ricin and shiga toxins to rationally design better inhibitors against these two toxins. In addition, the team has initiated nih-funded work in a collaborative effort with researchers at Virginia commonwealth university that involves structural characterization of a conserved streptococcal membrane protein that affects manganese utilization.rna lab: the rna research conducted at nysbc focuses on understanding how the 3-dimensional structures of rna form and how this structure, conformational dynamics, and interactions with other molecules enable diverse biological function. This nih-funded effort is primarily centered on understanding rnas of viral origin, with particular interest in how these viral rnas interact with the cellular machinery and manipulate that machinery. The rna group consists of researchers at several levels of training and experience, who employ and integrate biochemical, biophysical, structural, and bioinformatic approaches. This research program is world respected and frequently publishes in the highest impact journals.

Financial Efficiency

• Mission deployment rate: 100%; rating input score 100
• Program expense ratio: 83.6%; rating input score 84
• Fundraising efficiency: Limited

Transparency & Controls

• Consistency checks: 100%; rating input score 100; 62nd percentile among comparable filings
• Pay-setting controls: 1 of 6 controls in place; rating input score 17
  • Compensation committee: Pass
  • Independent consultant: Missing
  • Other Form 990s reviewed: Missing
  • Written employment contract: Missing
  • Compensation survey or study: Missing
  • Board or committee approval: Missing
• Foreign activity oversight: Limited
• Grant itemization coverage: 100%; rating input score 100; 72nd percentile among comparable filings
• Major donor itemization: Yes; rating input score 100
• Related-party transparency: Limited

Accountability

• Independent voting board: 100%; rating input score 100; 66th percentile among comparable filings
• Governance controls: 7 of 8 controls in place; rating input score 88
  • Conflict-of-interest policy: Pass
  • Whistleblower policy: Pass
  • Document-retention policy: Pass
  • CEO compensation review process: Pass
  • Other executive compensation review process: NotApplicable
  • Form 990 shared with the board: Fail
  • Board meeting minutes documented: Pass
  • Audit committee oversight: Pass
  • Independent financial-statement audit: Pass

Sustainability

• Operating margin: -42.6%; rating input score 2; 2nd percentile among comparable filings
• Total-asset coverage ratio: 4.71; rating input score 84; 84th percentile among comparable filings
• Liabilities to assets ratio: 0.08; rating input score 76; 76th percentile among comparable filings
• Officer compensation ratio: 8.6%; rating input score 27; 27th percentile among comparable filings

Growth

• Program expense growth: 7.1% per year; rating input score 100; 56th percentile among comparable filings
• Revenue growth: 6.4% per year; rating input score 100; 55th percentile among comparable filings
• Asset growth: 7.6% per year; rating input score 100; 52nd percentile among comparable filings