Institute for in Vitro Sciences Inc

Nonprofit profile at a glance

EIN
522029668
IRS 990 coverage
2010–2025
Forms available
Form 990 2025
Location
Gaithersburg, MD, USA
Phone
3019476523
Rating
75
Verdict
SUPPORTED
Rating confidence
Moderate
Sector
Specialized Education Institutions

Reported finances

Revenue
$7,901,249
Expenses
$7,883,164
Assets
$5,555,372
Liabilities
$3,178,014

Source: IRS Form 990. Selected filing: tax year 2025. Amounts in USD.

Leadership & pay

13 people listed

Executive titles in this filing

  • AMANDA K ULREY (PRESIDENT)
  • RODGER D CURREN (CEO/BOARD CHAIR/SECRETARY)

Highest reported compensation

  • HOLGER P BEHRSING (DIRECTOR RESPIRATORY TOXICOLOGY): $181,262 total reported compensation
  • HANS A RAABE (CHIEF OPERATING OFFICER/TREASURER): $172,796 total reported compensation
  • AMANDA K ULREY (PRESIDENT): $167,797 total reported compensation

Source: IRS Form 990. Selected filing: tax year 2025. Names and roles reflect this filing, not necessarily current officeholders.

Overview

Mission

The mission of the institute for in vitro sciences (iivs) is to drive the optimization and application of scientifically robust in vitro methods that are accepted by regulatory agencies and adopted by industry worldwide. To create a forum in which industry, regulatory agencies and animal welfare organizations can work together to develop humane scientific tools for testing. To utilize our expertise to create educational and outreach programs that will expand the adoption of non-animal test methods around the globe.

What it reported doing in 2025

Education and outreach: iivs participates in numerous training activities for a variety of stakeholders including industry and regulatory scientists. These trainings are tailored for the specific audience and generally include lectures, hands-on demonstrations and data interpretation. Two major programs in which iivs participates are the physicians committee for responsible medicine nura training and the animal free safety assessment collaboration coordinated by humane society international. Iivs scientists were invited to participate in expert panels convened by the organization for economic cooperation and development (oecd) which harmonizes in vitro testing approaches for the worldwide scientific community. These panels discussed new methods for genetic toxicology, skin sensitization, eye irritation and skin corrosion. Iivs is leading efforts with industry consortia and 2 divisions of the u.s. Federal drug administration to apply non-animal methods for specific endpoints. Iivs is also involved in efforts to support the u.s. Environmental protection agency's goal to reduce reliance on animal models. Iivs staff hold board positions within societies that have the mission to work collaboratively to increase the use and acceptance of alternative methods, such as the american society for cellular and computational toxicology, the european society of toxicology in vitro, the u.s. Society of toxicology and the chinese society of toxicology.

Operating model

Revenue model
Earned-program. 89% of the money available for current operations came from fees and other program revenue.
Distribution model
Direct operator. The filing allocates 100% of reported program-service expenses outside its grant, affiliate-payment, and member-benefit lines. This expense classification does not rule out separately announced grant awards.

The verdict

SUPPORTED - A large share of available resources goes toward mission work and most filed governance safeguards are in place. The filing reports few safeguards for money sent abroad and the filing does not identify recipients for some grant dollars.

Rating breakdown

  • Financial Efficiency: 92
  • Transparency & Controls: 54
  • Accountability: 78
  • Sustainability: 24
  • Growth: 100

Detailed rating inputs

Financial Efficiency

  • Mission deployment rate: 93.7%; rating input score 94
  • Program expense ratio: 93.9%; rating input score 94
  • Fundraising efficiency: $38.86 raised per $1 spent on fundraising; rating input score 74; 74th percentile among comparable filings

Transparency & Controls

  • Consistency checks: 100%; rating input score 100; 63rd percentile among comparable filings
  • Pay-setting controls: 3 of 6 controls in place; rating input score 50
    • Compensation committee: Missing
    • Independent consultant: Missing
    • Other Form 990s reviewed: Pass
    • Written employment contract: Missing
    • Compensation survey or study: Pass
    • Board or committee approval: Pass
  • Foreign activity oversight: Scored; rating input score 0
  • Grant itemization coverage: Scored; rating input score 0
  • Major donor itemization: Yes; rating input score 100
  • Related-party transparency: Limited

Accountability

  • Independent voting board: 62.5%; rating input score 62; 12th percentile among comparable filings
  • Governance controls: 9 of 9 controls in place; rating input score 100
    • Conflict-of-interest policy: Pass
    • Whistleblower policy: Pass
    • Document-retention policy: Pass
    • CEO compensation review process: Pass
    • Other executive compensation review process: Pass
    • Form 990 shared with the board: Pass
    • Board meeting minutes documented: Pass
    • Audit committee oversight: Pass
    • Independent financial-statement audit: Pass

Sustainability

  • Operating margin: 0.2%; rating input score 27; 27th percentile among comparable filings
  • Total-asset coverage ratio: 0.7; rating input score 24; 24th percentile among comparable filings
  • Liabilities to assets ratio: 0.57; rating input score 13; 13th percentile among comparable filings
  • Officer compensation ratio: 13.9%; rating input score 24; 24th percentile among comparable filings

Growth

  • Program expense growth: 7.3% per year; rating input score 100; 48th percentile among comparable filings
  • Revenue growth: 6.7% per year; rating input score 100; 49th percentile among comparable filings
  • Asset growth: 8.5% per year; rating input score 100; 51st percentile among comparable filings

Details

  • Where the money goes: 93.7% of revenue deployed · 93.9% of spending went to programs
  • Governance: 5 of 8 board members independent · 9 of 9 filing controls reported
  • Programs: 2 filed program accomplishments · $7.4M in reported program spending
  • Leadership: top reported pay $181K · 13 people listed · 3 of 6 pay-setting controls reported
  • Consistency: 34 of 34 current checks pass
  • Schedules: 6 filed schedules · includes major donors, foreign activity, and executive pay
  • Filing history: 15 filing years from 2010 to 2025
  • Contacts: How to reach this organization
  • Money network: 8 filed money-flow records
  • Related organizations: Filed and resolved organization relationships.
  • Grant readiness: Federal tax and exclusion status, award history, and grant-maker relationships.
  • People: Everyone the filings name, and which of them the filings identify by more than a name.
  • Staff and benefit plans: Retirement and health plans the organization files with the Department of Labor, and the people in them.

Key Signals

Signals prioritize questions for review. They are not findings of misconduct.

  • High — Transparency & Controls: Foreign activity oversight scored 0/100.
  • High — Transparency & Controls: Grant itemization coverage scored 0/100.
  • High — Sustainability: Operating margin scored 27/100.
  • High — Sustainability: Total-asset coverage ratio scored 24/100.
  • High — Sustainability: Liabilities to assets ratio scored 13/100.
  • High — Sustainability: Officer compensation ratio scored 24/100.