Grace Science Foundation
Nonprofit profile at a glance
- EIN
- 465727883
- IRS 990 coverage
- 2014–2024
- Forms available
- Form 990 2024
- Location
- Menlo Park, CA, USA
- Phone
- 6507464591
- Rating
- 76
- Verdict
- SUPPORTED
- Rating confidence
- Moderate
- Sector
- Medical Research N.E.C.
Reported finances
- Revenue
- $943,011
- Expenses
- $1,519,386
- Assets
- $2,224,370
- Liabilities
- $1,004
Source: IRS Form 990. Selected filing: tax year 2024. Amounts in USD.
Leadership & pay
7 people listed
Executive titles in this filing
- Matthew Wilsey (President)
People named in this filing
- Matthew Wilsey (President)
- Egon Durban (Chief Financial Officer)
- KEN DRAZAN (Secretary)
Selected names, not a complete roster or a statement of current roles. Open leadership details for the complete filed list.
Source: IRS Form 990. Selected filing: tax year 2024. Names and roles reflect this filing, not necessarily current officeholders.
Overview
Mission
The mission of the foundation is to support and fund the development of life-saving treatment for patients that are deficient in the n-glycanese enzyme and those suffering from related genetic diseases. The activities of the foundation will involve providing grant funding to hospitals and medical resesarch facilities which are conducting medical research in various fields relating to the search for understnading and treatment of this condition, fostering collaboration between academia, research institutions, hospitals, private companies, and governmental agencies.
What it reported doing in 2024
THE UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER (YAN LAB) Team continues work generating and characterizing several mouse models of NGLY1 Deficiency, including models in which the gene is inactivated in certain tissues and conditionally after birth. These mouse models have allowed them to characterize neurological phenotypes including neuronal loss, neuropathological changes, inflammation, sensory and motor defects, and disease associated biomarkers, all of which are also observed in NGLY1 Deficiency patients These animal models provide a foundation for testing candidate therapies, including gene therapies and small molecule drugs. The team has also found that NGLY1 Deficiency in mice triggers a specific innate immune pathway mediated by the cGAS/STING pathway. Using genetic and pharmacological approaches, the team has uncovered three different targets that can be modulated to reduce disease associated phenotypes and improve survival.
Operating model
- Revenue model
- Donor-supported. 92% of the money available for current operations came from contributions and gifts.
- Distribution model
- Grant intermediary. The nonprofit sent 96% of its reported program spending out as grants.
The verdict
SUPPORTED - A large share of available resources goes toward mission work and the filed numbers largely add up. Some filing-based governance responses are negative or unanswered and the filing reports few safeguards for money sent abroad.
Rating breakdown
- Financial Efficiency: 86
- Transparency & Controls: 75
- Accountability: 64
- Sustainability: 36
- Growth: 100
Detailed rating inputs
Financial Efficiency
- Mission deployment rate: 100%; rating input score 100
- Program expense ratio: 91.6%; rating input score 92
- Fundraising efficiency: Limited
Transparency & Controls
- Consistency checks: 100%; rating input score 100; 63rd percentile among comparable filings
- Pay-setting controls: Limited
- Foreign activity oversight: Scored; rating input score 0
- Grant itemization coverage: 100%; rating input score 100; 76th percentile among comparable filings
- Major donor itemization: Yes; rating input score 100
- Related-party transparency: Limited
Accountability
- Independent voting board: 100%; rating input score 100; 63rd percentile among comparable filings
- Governance controls: 1 of 7 controls in place; rating input score 14
- Conflict-of-interest policy: Pass
- Whistleblower policy: Fail
- Document-retention policy: Fail
- CEO compensation review process: NotApplicable
- Other executive compensation review process: NotApplicable
- Form 990 shared with the board: Fail
- Board meeting minutes documented: Fail
- Audit committee oversight: Missing
- Independent financial-statement audit: Fail
Sustainability
- Operating margin: -61.1%; rating input score 2; 2nd percentile among comparable filings
- Total-asset coverage ratio: 1.46; rating input score 55; 55th percentile among comparable filings
- Liabilities to assets ratio: 0; rating input score 81; 81st percentile among comparable filings
- Officer compensation ratio: 0%; rating input score 81; 81st percentile among comparable filings
Growth
- Program expense growth: 11.4% per year; rating input score 100; 67th percentile among comparable filings
- Revenue growth: 1.2% per year; rating input score 100; 20th percentile among comparable filings
- Asset growth: 8.3% per year; rating input score 100; 53rd percentile among comparable filings
Details
- Where the money goes: 100% of revenue deployed · 91.6% of spending went to programs
- Governance: 7 of 7 board members independent · 1 of 7 filing controls reported
- Programs: 17 filed program accomplishments · $1.4M in reported program spending
- Leadership: top reported pay $0 · 7 people listed
- Consistency: 20 of 20 current checks pass
- Schedules: 5 filed schedules · includes major donors, foreign activity, and grants
- Filing history: 9 filing years from 2014 to 2024
- Contacts: How to reach this organization
- Money network: 13 filed money-flow records
- Related organizations: 13 filed related-organization links
- Grant readiness: Federal tax and exclusion status, award history, and grant-maker relationships.
- People: Everyone the filings name, and which of them the filings identify by more than a name.
Key Signals
Signals prioritize questions for review. They are not findings of misconduct.
- High — Accountability: Governance controls: 5 of 6 not reported.
- High — Transparency & Controls: Foreign activity oversight scored 0/100.
- High — Sustainability: Operating margin scored 2/100.
- Review — Sustainability: Total-asset coverage ratio scored 55/100.