Alzheimer's Association

What it reported doing in 2024

Research - see schedule o for detailsresearchthe alzheimer's association is at the forefront of the alzheimer's scientific field, globally connecting researchers in the quest to find methods of diagnosis, treatment, prevention and ultimately cures for all the diseases that cause cognitive impairment and dementia. The alzheimer's association implements an aggressive global research and science program strategically designed to accelerate progress by fostering innovation, identifying and closing critical knowledge gaps, developing and disseminating tools, and nurturing scientific talent.as the largest nonprofit funder of alzheimer's and dementia research, the alzheimer's association is committed to accelerating the global progress of new treatments, preventions and, ultimately, a cure. With over 20 funding programs offered across the entire spectrum of science to investigators at all career-levels, the alzheimer's association is currently committed to over $450 million to over 1,200 projects in 56 countries. In addition, the alzheimer's association's part the cloud funding program is designed to accelerate the transition of potential therapies from laboratory testing to clinical trials. Since 2012, the part the cloud initiative has raised nearly $90 million to accelerate scientific progress in funding the most promising early phase clinical studies.the alzheimer's association seeks to fund and advance best-in-class research and works with collaborators around the globe from all sectors to hasten this progress. An example of the high risk, high reward funding, the alzheimer's association funded the development pittsburgh compound b (pib), the first radiotracer capable of showing beta-amyloid in the living brain during a positron emission tomography (pet) scan. This sppurred significant investment in this area of research, leading to three now fda-approved tracers for amyloid pet. Identifying beta-amyloid in the living brain can be used to support the diagnosis of alzheimer's and also lets researchers determine if an experimental drug successfully decreases this hallmark alzheimer's protein providing invaluable information about disease progression. Another example, the alzheimer's association u.s. Study to protect brain health through lifestyle intervention to reduce risk (u.s. Pointer) is a two-year clinical trial to evaluate whether lifestyle interventions that simultaneously target many risk factors protect cognitive function in older adults who are at increased risk for cognitive decline. U.s. Pointer is the first study of its kind to be conducted in a large diverse and representative group of americans across the country. This landmark study reported out the topline results in july 2025, demonstrating that two lifestyle interventions targeting a combination of physical activity, improving nutrition, cognitive and social challenge and health monitoring improved cognition in older adults at risk of cognitive decline. Further, while both interventions improved cognition, the cognitive benefits were even greater for the partiicpants in the more structured intervention group, helping to protect thinking and memory from the normal decline that often comes with aging over the two-year period of the study. The alzheimer's association has also launched the nation's first alzheimer's network for treatment and diagnostics (alz-net) which is a voluntary health care provider-enrolled patient network that collects clinical and safety data for patients treated with new fda-approved alzheimer's disease therapies and tracks the long-term health outcomes associated with their use in real-world settings.alz-net is a resource for evidence gathering, information sharing and education across the clinical and research communities to help improve brain health outcomes for patients.the alzheimer's association has been a catalyst and convener for more than 40 years. The alzheimer's association offers year-round opportunities for the scientific commun

Financial Efficiency

• Mission deployment rate: 82.4%; rating input score 82
• Program expense ratio: 78.5%; rating input score 78
• Fundraising efficiency: $5.55 raised per $1 spent on fundraising; rating input score 24; 24th percentile among comparable filings

Transparency & Controls

• Consistency checks: 95.2%; rating input score 95; 35th percentile among comparable filings
• Pay-setting controls: 5 of 6 controls in place; rating input score 83
  • Compensation committee: Pass
  • Independent consultant: Pass
  • Other Form 990s reviewed: Pass
  • Written employment contract: Missing
  • Compensation survey or study: Pass
  • Board or committee approval: Pass
• Foreign activity oversight: 4 of 8 controls in place; rating input score 50
  • Claims monitoring procedures: Pass
  • Requires narrative reports: Pass
  • Conducts field audits: Limited
  • May suspend future funding: Pass
  • Requires financial reports: Pass
  • Conducts site visits: Limited
  • Requires grant agreements: Limited
  • May require repayment: Limited
• Grant itemization coverage: 100%; rating input score 100; 77th percentile among comparable filings
• Major donor itemization: Limited
• Related-party transparency: Yes; rating input score 100

Accountability

• Independent voting board: 100%; rating input score 100; 77th percentile among comparable filings
• Governance controls: 9 of 9 controls in place; rating input score 100
  • Conflict-of-interest policy: Pass
  • Whistleblower policy: Pass
  • Document-retention policy: Pass
  • CEO compensation review process: Pass
  • Other executive compensation review process: Pass
  • Form 990 shared with the board: Pass
  • Board meeting minutes documented: Pass
  • Audit committee oversight: Pass
  • Independent financial-statement audit: Pass

Sustainability

• Operating margin: -4.7%; rating input score 13; 13th percentile among comparable filings
• Total-asset coverage ratio: 1.09; rating input score 43; 43rd percentile among comparable filings
• Liabilities to assets ratio: 0.41; rating input score 44; 44th percentile among comparable filings
• Officer compensation ratio: 1.9%; rating input score 57; 57th percentile among comparable filings

Growth

• Program expense growth: 10% per year; rating input score 100; 74th percentile among comparable filings
• Revenue growth: 10.6% per year; rating input score 100; 79th percentile among comparable filings
• Asset growth: 10.8% per year; rating input score 100; 74th percentile among comparable filings