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lives until we achieve our vision of a world without t1d. jdrf collaborates with a wide spectrum of partners and is the only organization with the scientific resources, regulatory influence and a working plan to bring life-changing therapies from the lab to the t1d community. part iii: statement of program service accomplishments line 4a ($98,317,342)jdrf is the only global organization with a strategic research plan to end t1d. our plan ensures that there will be an ongoing stream of life-changing therapies moving through the research pipeline from development to the marketplace that lessen the impact of t1d until we eliminate the disease from people's lives completely and create a world without t1d. jdrf research programs are focused on driving the research pipeline to expedite and sustain meaningful scientific progress which is key to delivering progressively advanced t1d therapies. to accomplish this, jdrf is: 1) driving research across the entire scientific and development spectrum, from discovery in the laboratory to clinical studies to delivery to patient; 2) collaborating with public, private, academic, and corporate partners to expedite delivery of real-world solutions; and 3) advocating with governments, regulators, and health insurers for progress that will improve lives today and lead to a cure tomorrow. jdrf research is focused on the following seven key therapy areas. artificial pancreas - systems that can deliver more effective and precise insulin and multi-hormone therapy. complications - therapies that prevent or better treat t1d-related damage such as eye and kidney disease. encapsulation - replacement cell therapies that can provide long-term relief from insulin therapy. glucose control - treatments that will improve the body's glycemic and metabolic balance through innovative and personalized therapies above and beyond the use of insulin alone. smart insulin - novel insulins that can turn on and off in response to changing blood-glucose levels. restoration - restoring the body's ability to produce insulin, which would provide a biological cure for t1d. prevention - therapies that will keep individuals, especially those at higher risk, from ever developing t1d. line 4b ($21,415,048) to help define and direct its research programs and to foster collaboration with others involved with t1d research, jdrf organizes scientific meetings, symposia, workshops, and conferences. depending on their specific goal, these events may include scientific experts from academia, governments, and industry, regulators, jdrf volunteers, and/or representative people with t1d or those who have a family member with t1d. this work provides opportunities to review research proposals and ensure jdrf's research strategy is aligned with the needs of the t1d community and for jdrf to provide scientific updates on the research it is funding and managing. these events also enhance jdrf's ability and opportunity to forecast future scientific directions, judge the potential efficiency and effectiveness of new research pathways, influence the direction of non-jdrf research programs, and identify gaps where jdrf can focus its funding to make the most impact. these events strengthen jdrf's leadership role in t1d research and enables it to drive the most effective strategic funding plan to bring about a continuous flow of life-changing therapies and, ultimately, a cure for t1d. these are also key to helping align global efforts towards a common goal of creating a world without t1d. line 4c ($51,463,000) because of its leading role in t1d research globally, jdrf is in a unique position to provide public education about diabetes, especially t1d, and its complications. jdrf is a recognized, authoritative source of information about t1d and t1d-related research and research progress. jdrf's efforts impact not only the millions of people with the disease and their families, but also those at risk for developing the disease, and the general public. jdrf educates people about the warning signs of t1d, which can be profoundly helpful in ensuring timely diagnoses and reducing the potential, short-term, life-threatening consequences of the disease. jdrf also provides key information about current research directions and progress, and about human clinical trials in which people with the disease can participate to help test potential new therapies. jdrf staff in the national office, in local chapter offices across the united states and in affiliate offices around the globe routinely organize and support programs designed to help people identify and diagnose t1d earlier and to help people with t1d stay healthier so that they can benefit from a cure and treatments as they are developed. 990 review process form 990 section b, part vi, question 11b the first step in the form 990 review process begins at the finance level with the organization's tax manager working with outside tax advisors to prepare the return and all 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we work tirelessly to accelerate breakthroughs to cure, prevent and treat type 1 diabetes (t1d). we continually expand our scientific knowledge, our connections and collaborations, our partners and global presence to unlock the science that will stop t1d. while we fight for a cure, we strive just as hard to develop therapies to help people right now. jdrf and our scientists are leading t1d research around the world. we address key gaps to move research faster and farther across the development pipeline and to translate breakthroughs into new therapies for people with t1d. this enables us to advance science with the most potential and to drive research that attracts more resources and scientific expertise to the field. we invest in the early stages, allowing researchers to pursue innovative ideas and approaches that will lead to breakthrough treatments. jdrf also works to drive new therapies and technologies to market so they get into the hands of people with t1d more quickly. and we 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a global community of support for anyone affected by t1d. from funding innovative research to advocating for government action and providing a support structure for our community, no other organization does more to fight t1d than jdrf. since our founding, jdrf has funded more than $2.5 billion in research and has made significant progress in understanding and fighting the disease. our actions - through advocacy and our own investments in t1d research - influence other organizations, corporations and government agencies to follow our lead and direct additional funding toward t1d research. today, every $1 jdrf invests in research attracts an additional $2.25 to the field. for fiscal year 2023, jdrf's approximately $138.4 million in direct funding attracted $311 million in additional investment in t1d research from u.S. and international government, ngos and charitable organizations, and corporate partners.","year":2022,"name":"JDRF 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impact of t1d from people's lives until we achieve our vision of a world without t1d. jdrf collaborates with a wide spectrum of partners and is the only organization with the scientific resources, regulatory influence and a working plan to bring life-changing therapies from the lab to the t1d community. part iii: statement of program service accomplishments line 4a ($72,354,198) jdrf is the leading global organization funding type 1 diabetes (t1d) research. our mission is to accelerate life-changing breakthroughs to cure, prevent and treat t1d and its complications. to accomplish this, jdrf has invested nearly $2 billion in research funding since our inception. we are an organization built on a grassroots model of people connecting in their local communities, collaborating regionally for efficiency and broader fundraising impact, and uniting on a national stage to pool resources, passion, and energy. we collaborate with academic institutions, policymakers, and corporate and industry partners to develop and deliver a pipeline of innovative therapies to people living with t1d. our staff and volunteers in more than 100 locations throughout the united states and our six international affiliates are dedicated to advocacy, community engagement and our vision of a world without t1d. for more information, please visit www.Jdrf.Org line 4b ($19,611,575) jdrf maintains an in-house team of skilled scientific, policy and government relations professionals with credentials including phds, mds, mbas, mas and others, each of whom play a critical role in leading and supporting the research strategy and the deployment of research funds from jdrf and others to create a world without type one diabetes. in their respective responsibilities, these professionals perform the functions of identifying, evaluating and influencing groundbreaking research being funded by jdrf, other foundations, governments and industry to achieve the organization's mission. these professionals also work with regulatory and policy officials to ensure research can proceed without delay and that research results are well understood by health care decision makers. as part ofthese efforts, jdrf organizes and funds scientific meetings, symposia, and conferences with the purpose of reviewing research proposals, ensuring that jdrf's research strategy is well-aligned with the needs of the t1d community and to enable jdrf to provide scientific updates on the research it manages. this work also enhances jdrf's ability to forecast future scientific direction, to judge the potential efficiency and effectiveness of new pathways and to identify gaps where jdrf can focus its funding to make the most impact. jdrf's leadership in these areas enables it to drive a strategic plan to bring about a continuous flow of life-changing therapies and ultimately, a cure for t1d. line 4c ($53,281,787) because of its leading role in diabetes research globally, jdrf is in a unique position to provide public education about diabetes and its complications. jdrf's efforts impact not only the millions of people with the disease and their families, but also those at risk for developing the disease, and the general public. jdrf educates people about the warning signs of diabetes, which can be profoundly helpful in ensuring timely diagnoses and reducing the potential, short-term, catastrophic consequences of type 1 diabetes. jdrf also provides key information about current research directions and progress, and about human clinical trials in which people with the disease can participate (including via jdrf's clinical trials connection service). jdrf chapters around the nation are committed to helping people identify and diagnose diabetes earlier and stay healthier so that they can benefit from a cure and treatments as they are developed.","year":2014,"name":"JDRF 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committed to funding the development of new therapies and treatments to keep people with t1d healthier, longer, until a cure is found. its strength lies in its exclusive focus and singular influence on the worldwide effort to end t1d. jdrf works every day to change the reality of this life-threatening autoimmune disease for millions of people - and to prevent anyone else from contracting the disease - by funding research, advocating for government support of research and new therapies, ensuring new therapies and technologies come to market, and connecting and engaging the t1d community. jdrf has funded more than $2 billion in research to date and made significant progress in understanding and fighting the disease. jdrf has played a role in nearly every t1d therapeutic advance of the past four decades, including the fda-approved hybrid closed-loop artificial pancreas system in september 2016. part iii: statement of program service accomplishments line 4a ($75,084,432) research funding jdrf funds research with the greatest potential to cure, prevent and treat type 1 diabetes (t1d). its strength lies in its exclusive focus and singular influence on the worldwide effort to end t1d. jdrf has committed more than $2 billion to this research since 1970. the full impact of jdrfs research investment extends well beyond direct funding. jdrf leverages partnerships with academia, industry and clinicians to ensure that the most promising research opportunities are funded and accelerated. jdrf often provides early stage funding to research projects, and the results of those projects often lead to follow-on participation from many other entities--both other non-for-profit funders and corporations. jdrf's research team is staffed by accomplished experts and leaders in the field of t1d science and medicine who guide the organization's funding efforts every step of the way. jdrfs highest priority remains funding research to deliver a cure for t1d and its complications. at the same time, jdrf is focused on developing better treatments that will transform the way people with t1d treat the disease today to help them live healthier lives now and in the future. the foundation's diversified research portfolio includes the following therapy areas: artificial pancreas: artificial pancreas systems use technology to replicate the operation of a normal human pancreas and are one of the most revolutionary advances in diabetes care since the discovery of insulin. these systems link continuous glucose monitors and insulin pumps to smart software so that the right amount of insulin is delivered at the right time. glucose control: glucose-responsive insulins(gris)--or smart insulins--promise to be a game-changer in blood-sugar management. gris will be the first-ever insulin formulation that turns on and off in response to blood sugar highs and lows. jdrf is also funding research that explores the benefits of combining novel or repurposed drugs with standard insulin therapy. beta cell replacement: this therapy, also known as encapsulation, can be implanted to provide long-term relief from insulin dosing without the need for immune suppression. jdrf-supported scientists are improving biomaterials for encapsulation devices to protect implanted beta cells from autoimmune attack, among other strategies. beta cell restoration: this drug or biologic-based therapy represents a full biological cure for people with t1d. it stimulates restoration of the bodys own beta cells and the capacity to produce insulin. we are repurposing drugs that may reduce beta cell stress and/or induce survival, as well as funding immune therapies that will stop the disease in its tracks. complications: jdrf-funded research has already yielded new treatments for diabetic eye and kidney disease, the most common complications. today, researchers are identifying biomarkers and accelerating the completion of clinical trials of potential treatments. prevention: jdrf research has identified a number of potential triggers, including viruses and environmental conditions, which could open the door to new vaccines and other prevention strategies. the organization is also funding efforts to stall the progression of the disease in those at risk or newly diagnosed. for more information, visit jdrf.Org/research. line 4b ($21,188,795) research consortia jdrf maintains an in-house team of skilled scientific, policy and government relations professionals with credentials, including phd.'s, md's, mbas, mas, and others, each of whom plays a critical role in leading and supporting the research strategy and the disbursement of research funds from jdrf and others to create a world without type 1 diabetes (t1d). in their respective responsibilities, these professionals perform the functions of identifying, evaluating and influencing groundbreaking research being funded by jdrf, other foundations, governments and industry to achieve the organization's mission. these professionals also work with regulatory and policy officials to ensure research can proceed without delay and that research results are well understood by healthcare decision makers. as part of these efforts, jdrf organizes and funds scientific meetings, symposia, and conferences with the purpose of reviewing research proposals, ensuring that jdrf's research strategy is well aligned with the needs of the t1d community and allowing jdrf to provide scientific updates on the research it manages. jdrf also works with its external research advisory committee (rac), which is composed of professionals who are internationally renowned for their expertise in research as well as the care and treatment of those with t1d. the rac advises on matters of policy pertaining to research philosophy and procedures to help the organization be most effective. all of this work to convene the best minds in the field enhances jdrf's ability to forecast future scientific direction, to judge the potential efficiency and effectiveness of new pathways and to identify gaps where jdrf can focus its funding to make the most impact. it is from this position of strength that jdrf identified opportunities where the foundation can make significant advances in the near future and launched a five-year strategic plan in 2015 to accelerate progress to cure, prevent and treat t1d and its complications line 4c ($52,293,201) public education because of its leading role in type 1 diabetes (t1d) research globally, jdrf is in a unique position to provide public education about diabetes and its complications. jdrf's efforts impact not only the millions of people with the disease and their families and the general public, but also those at risk for developing the disease. type 1 diabetes strikes both children and adults suddenly, and the adjustment period following a diagnosis can be overwhelming. jdrf educates people about the warning signs of t1d, which can be profoundly helpful in ensuring timely diagnoses and reducing the potential, short-term, catastrophic consequences of t1d. the foundation provides outreach services and resources, like the jdrf bag of hope and the jdrf adult t1d care kit, for newly diagnosed children and adults, respectively, and toolkits for managing all ages and stages of life with t1d. jdrf also provides information and updates about current research directions and progress and about human clinical trials that are seeking participants (including through jdrf's clinical trials connection matching tool: www.Jdrf.Org/research/clinical-trials). through all of its u.S. chapters and online, jdrf supports the t1d communitys diverse needs, connecting people with local support, expert resources and the worldwide effort to end this serious disease.","year":2015,"name":"JDRF 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